Virginijus Siksnys

細胞生物学研究

Virginijus Siksnys

特任教授

BiochemistryCRISPR-Cas9

トピックス

  • The Kavli Prize in Nanoscience 2018 was awarded to Dr. Virginijus Siksnys for the invention of CRISPR-Cas9, a precise nanotool for editing DNA, causing a revolution in biology, agriculture, and medicine.

2019-

Specially Appointed Professor, School of Life Science and Technology, Tokyo Institute of Technology

2019-

Distinguished Professor/Chief Staff Scientist, Vilnius University

2010-2018

Chief Staff Scientist/ Head of Department, Institute of Biotechnology, Vilnius University

2002-2010

Professor, Vilnius University (part time)

2002-2010

Chief Staff Scientist/ Head of Department, Institute of Biotechnology, Vilnius University

1996-2002

Senior Staff Scientist, Head of Laboratory, Institute of Biotechnology, Vilnius University

1994

Visiting Scientist, Max-Planck-Institute of Biochemistry, Martinsried, Germany

1987-1996

Senior Research Fellow/Group Leader Institute of Applied Enzymology, Vilnius University

1985-1986

Senior Research Fellow, Institute of Applied Enzymology, Vilnius University

1981-1985

Junior Research Fellow, Institute of Applied Enzymology, Vilnius University

2018

The Kavli Prize

2018

Honorary doctorate of University of Bristol

2018

Lithuania National Science Award

2017

NovoNordisk Novozyme Prize

2016

Grand Duke Gediminas Order of the State of Lithuania

2016

Warren Alpert Prize

2015

St. Christophorus award of Vilnius city

2012

Lithuania’s Scientist of the year

2001-2005

Howard Hughes Medical Institute International scholarship

2001

Lithuania National Science Award

2017

Kazlauskiene M, Kostiuk G, Venclovas Č, Tamulaitis G, Siksnys V. A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems. Science. 2017, 357, 605-60.

2016

Kazlauskiene M, Tamulaitis G, Kostiuk G, Venclovas Č, Siksnys V. Spatiotemporal Control of Type III-A CRISPR-Cas Immunity: Coupling DNA Degradation with the Target RNA Recognition. Mol Cell. 2016, 62, 295-306.

2015

Glemzaite, M. Balciunaite, E. Karvelis, T. Gasiunas, G. Alzbutas, G. Jurcyte, A. Anderson, E.M. Maksimova, M. Smith, A.J. Lubys, A. Zaliauskiene, L. Siksnys, V. Targeted gene editing by transfection of in vitro reconstituted Streptococcus thermophilus Cas9 nuclease complex, RNA Biology. 2015,12, 1-4.

2015

Karvelis T, Gasiunas G, Young J, Bigelyte G, Silanskas A, Cigan M, Siksnys V. Rapid
characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements. Genome Biol. 2015, 16, 253.

2014

Tamulaitis G. Kazlauskiene, M. Manakova, M. Venclovas, C. Nwokeoji, A.O. Dickman, M.J. Horvath, P. Siksnys V. Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus. Molecular Cell 2014, 56, 506-17.

2013

Sinkunas T, Gasiunas G, Waghmare SP, Dickman MJ, Barrangou R, Horvath P, Siksnys V. In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus. EMBO J. 2013; 2, 385-94.

2013

Karvelis T, Gasiunas G, Miksys A, Barrangou R, Horvath P, Siksnys V. crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus. RNA Biol. 2013, 10, 841-51.

2012

Gasiunas G, Barrangou R, Horvath P, Siksnys V. Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci U S A. 2012, 109, E2579-86.

2011

Sinkunas T, Gasiunas G, Fremaux C, Barrangou R, Horvath P, Siksnys V. Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system. EMBO J. 2011, 30:1335-42.

2011

Sapranauskas R, Gasiunas G, Fremaux C, Barrangou R, Horvath P, Siksnys V. The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli. Nucleic Acids Res. 2011, 39, 9275-82.