Protein ChemistryRedox proteinsBioinorganic Chemistry
Prof. Shyamalava Mazumdar is a Senior Professor at the Department of Chemical Sciences, Tata Institute of Fundamental Research (TIFR), Mumbai, India. He completed his Ph.D on NMR of model hemes in 1990, and subsequently worked as a Post doctoral fellow with Prof. HAO Hill, FRS at University of Oxford. He joined TIFR as a graduate student in 1985 and later became an academic faculty leading the Bioinorganic Chemistry programme at the Institute.
The research activities of Prof. Mazumdar are directed to the study of structural and functional aspects of the active site formed by the metal ion and the surrounding amino acids in iron and copper containing metalloenzymes and metalloproteins. He also has been working on developing Bio-nano conjugation and investigating invitro catalysis by modified metalloenzymes.
Prof. Mazumdar has made significant contributions to unraveling the role of the active site environment on the stability and function of cytochrome P450 enzymes. He has received several recognision including Bronze medal from the Chemical Research Society, India, and Fellowship of the National Academy of Sciences, India.
His work has been well recognized internationally, published more than 100 peer reviewed papers, and he has given invited lectures at various International conferences. He was a visting Professor at the Nagoya University, Japan and at the Princeton university, USA. He also visited the Frankfurt University, Germany as a Humboldt Research fellow. He is the Indian representative in the Steering Committee of the Asian Biological Inorganic Chemistry Conferences (AsBIC), and was the convenor of the AsBIC-II held at Goa in 2004. He also organized the Symposia on Advances in Biological Inorganic Chemistry series which is the only major conference in the area in India.
The laboratory of Prof Takafumi Ueno is famous for pioneering work on the iron storage protein ferritin, especially in its applications in developing novel biomaterials. My group at TIFR, Mumbai (India) is interested in biomaterials and biocatalytic applications of metal containing proteins. The WRHI has provided with the unique opportunity to me to collaborate with Prof Ueno and this would facilitate developing joint research programmes of mutual interests in engineering the ferritin with designs to promote novel catalytic or materials applications. The expertise of protein crystallization and imaging at the laboratory of Prof Ueno compliments the expertise of protein engineering, kinetics and spectroscopic facilities of my group. Thus this collaboration will bring two of our groups closer together . We have already initiated students' exchange from my lab to here and hope to host students from Prof Ueno's lab at my group in India in future.
As a part of the visit and a Specially invited Professor at the Tokyo Tech, I am also happy to teach the students here and I am currently teaching a short course on Bioinorganic Chemistry.
Overall, I am grateful to the WRHI for the honour and for giving this opportunity to visit and collaborate with Prof Takafumi Ueno.
Specially Appointed Professor, School of Life Science and Technology, Tokyo Institute of Technology
Senior Professor (I), Tata Institute of Fundamental Research
Professor, Tata Institute of Fundamental Research
Fellow, Reader and Associate Professor, Tata Institute of Fundamental Research
Alexander von Humboldt Research Fellow at Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
Visiting Research Scientist, Chemistry Department, Princeton University
Post Doctoral Fellow, University of Oxford with Prof. H.A. O. Hill, FRS
Bronze Medal, Chemical Research Society of India
Anil Kumar Bose Memorial Award, INSA, New Delhi, INDIA
Geeta Udgaonkar Award for best thesis, TIFR, Mumbai, INDIA
NMR Medal for Yound Scientists, BRUKER INDIA
INSA Medal for Young Scientists, INSA, New Delhi, INDIA
Prof. B.C. Haldar Memorial Award, Indian Chemical Society, Calcutta, INDIA
Electrospray Ionization Mass Spectrometry: A Technique to access the information beyond the molecular weight of the analyte. Shibdas Banerjee and Shyamalava Mazumdar.Int. J. Anal. Chem. 2012 (2012), Article ID 282574, 40 pages
Sequence Specific Association of Tryptic Peptides with Multiwalled Carbon Nanotubes: Effect of Localization of Hydrophobic Residues. Megha S. Deshpande and Shyamalava Mazumdar. Biomacromolecules, (2012), 13 (5), 1410–1419
Role of the Surface-Exposed Leucine 155 in the Metal Ion Binding Loop of the CuA Domain of Cytochrome c Oxidase from Thermus thermophilus on the Function and Stability of the Protein. Manas Kumar Ghosh, Jitumani Rajbongshi, Debajani Basumatary, and Shyamalava Mazumdar. Biochemistry, (2012), 51 (12), 2443–2452
Selective Deletion of the Internal Lysine Residue from the Peptide Sequence by Collisional Activation. Shibdas Banerjee, Shyamalava Mazumdar. J. Am. Soc. Mass Spectrom. (2012) 23, 1967-1980
Biochemical and Molecular Dynamic Simulation Analysis of a Weak Coiled Coil Association between Kinesin-II Stalks. Harinath Doodhi, Swadhin Jana, Pavithra Devan, Shyamalava Mazumdar, Krishanu Ray. PloS ONE (2012) 10.1371/journal.pone.0045981
Oxygenation of Monoenoic Fatty Acids by CYP175A1, an Orphan Cytochrome P450 from Thermus thermophilus HB27. Sandeep Goyal, Shibdas Banerjee and Shyamalava Mazumdar. Biochemistry(2012), 51, 7880−7890
Thermodynamic effects of the alteration of the axial ligand on the unfolding of the thermostable cytochrome c. Rabindra Kumar Behera, Hiroshi Nakajima, Jitumani Rajbongshi, Yoshihito Watanabe, Shyamalava Mazumdar. Biochemistry (2013), 52(8), 1373–1384
Mechanism of copper incorporation in the subunit II of cytochrome c oxidase from Thermus thermophilus: Identification of intermediate species. Manas Kumar Ghosh, Priyanka Basak, and Shyamalava Mazumdar. Biochemistry (2013), 52 , 4620−4635
Role of Substituents on the Reactivity and Product Selectivity in the Reactions of Naphthalene Derivatives Catalyzed by the Orphan Thermostable Cytochrome P450, CYP175A1. Shibdas Banerjee, Sandeep Goyal, and Shyamalava Mazumdar Bioorganic Chemistry (2015) 62, 94–105
Regioselective Oxygenation of Polyunsaturated Fatty Acids by the Thermostable P450 from Thermus thermophilus HB27. Shibdas Banerjee, Dwaipayan Datta Gupta, and Shyamalava Mazumdar. Current Biotechnology, (2015), 4(3): 345 – 356
A molecular Fe-complex as a catalyst probe for in-gel visual detection of proteins via signal amplification. Sushma Kumari, Chakadola Panda, Shyamalava Mazumdar and Sayam Sen Gupta. Chem. Commun (2015), 51, 15257-15260, DOI: 10.1039/C5CC04399A
The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis. Swapnil S. Parhad, Deepa Jaiswal, Krishanu Ray, Shyamalava Mazumdar. Biochem Biophys Res Commun (2016), 472, 189-193
Mono-nuclear copper complexes mimicking the intermediates for the binuclear copper center of the subunit II of cytochrome oxidase: a peptide based approach. Dwaipayan Dutta Gupta, Dandamudi Usharani and Shyamalava Mazumdar. Dalton Trans., 2016, 45, 17624–17632
Ultrafast Dynamics of Hemin Aggregates on Femtosecond Time Scales. Arpita Nath, J. A. Dharmadhikari, A. K. Dharmadhikari, D. Mathur, S Mazumdar. Phys. Chem. Chem. Phys., 2017, 19, 26862-26869
Substitution of iron with cobalt in the prosthetic group of bacterial cytochrome P450: Effects on the stability and structure of the protein. Abhijit Mondal, Mriganka Das, Shyamalava Mazumdar. Inorganica Chimica Acta, 2019, 487, 398-404