木村 宏

細胞生物学研究

Hiroshi Kimura木村 宏

教授

エピジェネティクス 遺伝子発現制御ライブイメージング細胞核機能

トピックス

  • ヒストンH4メチル化の生細胞計測に関する論文が米国科学誌「Journal of Molecular Biology」に掲載されました。

  • 日本人で初めて「ロバート・フォイルゲン賞」を受賞しました。

  • 遺伝子活性化の生細胞計によりヒストンアセチル化の役割を解明した論文が英国科学誌「Nature」に掲載されました。

1996-2002

オックスフォード大学 博士研究員

2002-2003

東京医科歯科大学難治疾患研究所 助教授 

2003-2007

京都大学 医学研究科
先端領域融合医学研究機構 特任教授

2007-2014

大阪大学生命機能研究科 准教授

2014-2016

東京工業大学 生命理工学研究科 教授

2016-

東京工業大学 科学技術創成研究院 教授

2009

日本細胞生物学会論文賞

2015

Robert Feulgen Prize The Society for Histochemistry

2021

文部科学大臣表彰 科学技術賞(研究部門)

2020

Ioana Olan, Aled J. Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne S. L. Chan, Guy St.C. Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimura, Shamith A. Samarajiwa, Peter Fraser & Masashi Narita. Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence. Nat Commun. 11, Article number: 6049 (2020)

2020

Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato, Masaru Nakao, Naoki Goto, Hitoshi Kurumizaka, Yasuyuki Ohkawa & Hiroshi Kimura. Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input. Nature Protocols volume 15, pages3334–3360(2020)

2020

Yoko Hayashi-Takanaka, Yuto Kina, Fumiaki Nakamura, Leontine E. Becking, Yoichi Nakao, Takahiro Nagase, Naohito Nozaki, Hiroshi Kimura. Histone modification dynamics as revealed by multicolor immunofluorescence-based single-cell analysis.

2019

Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki, Genta Nagae, Yuki Katou, Shuichi Tsutsumi, Natsu Nakajima, Hiroshi Fukuhara, Atsushi Iguchi, Takahide Kohro, Yasuharu Kanki, Yutaka Saito, Mika Kobayashi, Akashi Izumi-Taguchi, Naoki Osato, Kenji Tatsuno, Asuka Kamio, Yoko Hayashi-Takanaka, Hiromi Wada, Shinzo Ohta, Masanori Aikawa, Hiroyuki Nakajima, Masaki Nakamura, Rebecca C McGee, Kyle W Heppner, Tatsuo Kawakatsu, Michiru Genno, Hiroshi Yanase, Haruki Kume, Takaaki Senbonmatsu, Yukio Homma, Shigeyuki Nishimura, Toutai Mitsuyama, Hiroyuki Aburatani, Hiroshi Kimura, Katsuhiko Shirahige. Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. Epigenetics & Chromatin volume 12, Article number: 77 (2019)

2019

Yuko Sato, Lennart Hilbert, Haruka Oda, Yinan Wan, John M Heddleston, Teng-Leong Chew, Vasily Zaburdaev, Philipp Keller, Timothee Lionnet, Nadine Vastenhouw, Hiroshi Kimura. Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis.

2019

Akihito Harada, Kazumitsu Maehara, Tetsuya Handa, Yasuhiro Arimura, Jumpei Nogami, Yoko Hayashi-Takanaka, Katsuhiko Shirahige, Hitoshi Kurumizaka, Hiroshi Kimura & Yasuyuki Ohkawa. A chromatin integration labelling method enables epigenomic profiling with lower input. Nature Cell Biology volume 21, pages287–296(2019)

2019

Ning Zhao, Kouta Kamijo, Philip D. Fox, Haruka Oda, Tatsuya Morisaki, Yuko Sato, Hiroshi Kimura & Timothy J. Stasevich. A genetically encoded probe for imaging nascent and mature HA-tagged proteins in vivo. Nat Commun. 10, Article number: 2947 (2019)

2018

Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D’Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018 May 9;9(1):1840.

2017

Imre L, Simándi Z, Horváth A, Fenyőfalvi G, Nánási P, Niaki EF, Hegedüs É, Bacsó Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabó G.
Nucleosome stability measured in situ by automated quantitative imaging. Sci Rep 2017, 7(1):12734.

Partolina M, Thoms HC, MacLeod KG, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun VS, Serrels B, Kimura H, Carragher NO, Kagansky A. Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array. Cell Death Discov 2017, 3:16077.

2016

Sato Y, Kujirai T, Arai R, Asakawa H, Ohtsuki C, Horikoshi N, Yamagata K, Ueda J, Nagase T, Haraguchi T, Hiraoka Y, Kimura A, Kurumizaka H, Kimura H. A genetically encoded probe for live-cell imaging of H4K20 monomethylation. J Mol Biol 428, 3885-3902, 2016.

2015

Hayashi-Takanaka Y, Maehara K, Harada A, Umehara T, Yokoyama S, Obuse C, Ohkawa Y, Nozaki N, Kimura H. Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies, Chromosome Res 23, 753-766, 2015.

Dias JD, Rito T, Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H, Pombo A. Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells, eLife 4, e11215, 2015.

2014

Strasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H. Regulation of RNA polymerace Ⅱ activation by histone acetylation in single living cells. Nature 516, 272-275, 2014.