岩﨑 博史

細胞生物学研究

Hiroshi Iwasaki岩﨑 博史

教授

染色体動態相同組換え接合型変換分子生物学分子遺伝学

研究プロジェクト

  • 岩﨑研究室は、相同組換えや接合型変換の分子機構を研究しています。

1991–2001

大阪大学微生物病研究所 助手

2001–2005

横浜市立大学 助教授

2005–2007

横浜市立大学 准教授

2007–2009

横浜市立大学 教授

2009 –

東京工業大学 教授

1992

井上研究奨励賞

2001

日本遺伝学会奨励賞

2013

文部科学大臣表彰 科学技術賞(研究部門)

2016

日本遺伝学会 木原賞

2018

New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe. Takahisa Maki, Naoto Ogura, James E Haber, Hiroshi Iwasaki, Genevieve Thon. PLoS Genet. (2018) 14(5):e1007424.

Establishment of DNA-DNA interactions by the cohesin ring. Yasuto Murayama, Catarina P. Samora, Yumiko Kurokawa, Hiroshi Iwasaki, Frank Uhlmann. Cell (2018) 172: 465-477.

2017

Holliday-junction resolvases that mediate chloroplast nucleoid segregation. Kobayashi Y, Misumi O, Odahara M, Ishibashi K, Hirono M, Hidaka K, Endo M, Sugiyama H, Iwasaki H, Kuroiwa T, Shikanai T, Nishimura Y. Science (2017) 356(6338), 631-634.

2014

Multiple regulation of rad51-mediated homologous recombination by fission yeast fbh1. Tsutsui Y, Kurokawa Y, Ito K, Siddique MS, Kawano Y, Yamao F and Iwasaki H. PLoS Genet. (2014) 28. e1004542. doi: 10.1371/journal.pgen.1004542.

2013

Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition. Murayama Y, Kurokawa Y, Tsutsui Y and Iwasaki H. Genes Dev. (2013) 27, 2299-2304.

2012

Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex. Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H and Shimizu T. Structure (2012) 20, 440-449.

2011

The fission yeast meiosis-specific Dmc1 recombinase mediates formation and branch migration of Holliday junctions by preferentially promoting strand-exchange in a direction opposite to that of Rad51. Murayama Y, Tsutsui Y and Iwasaki H. Genes Dev. (2011) 25, 516-527.

2009

RAD6-RAD18-RAD5 pathway-dependent tolerance to chronic low-dose UV light. Hishida T, Kubota Y, Carr AM, and Iwasaki H. Nature (2009) 457, 612-615.

2008

Reconstitution of DNA strand exchange mediated by Rhp51 recombinase and two mediators. Kurokawa Y, Murayama Y, Haruta-Takahashi N, Urabe I and Iwasaki H. PLoS Biol (2008) 6: e88.

Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases. Murayama Y, Kurokawa Y, Mayanagi K and Iwasaki H. Nature (2008) 451, 1018-1021.

2007

Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes. Akamatsu Y, Tsutsui Y, Morishita T, Siddique, MDP, Kurokawa, Y. Ikeguchi M, Yamao F, Arcangioli B and Iwasaki H. EMBO J. (2007) 26, 1352-1362.

2006

The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro. Haruta N, Kurokawa Y, Murayama Y, Akamatsu Y, Unzai S, Tsutsui Y and Iwasaki H. Nature Struct. Mol. Biol. (2006) 13, 823-730.

2003

Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast. Akamatsu Y, Dziadkowiec D, Ikeguchi M, Shinagawa H and Iwasaki H. Proc. Natl. Acad. Sci. USA. (2003) 100, 15770-15775.