Gilles Gregoire


Gilles Gregoire


Physical chemistrylaser spectroscopymass spectrometrytime‐resolved excited states dynamicsquantum chemistry calculationsbiomolecules, clusters


Directeur de recherche CNRS (DR2). PhD in Physics in 1999, Université Pierre et Marie Curie, Paris. In 2000, post doc with Pr. M.A. Duncan, University of Georgia, USA. CNRS researcher since 2001. From 2001 to 2014, member of the Laser Physics Lab, CNRS/Université Paris Nord. Former head of the national network CNRS “Isolated and solvated Molecular systems” and former group leader “Biomolecules and Spectroscopy” (LPL, Univ. Paris Nord). Since 2015, member of the Institute of Molecular Sciences Orsay, CNRS/Université Paris-Saclay. Actual head of the research network CNRS “CPPS : Chimie Physique Paris Saclay”.


Exciting collaboration with Pr. Masaaki Fujii’s group, world expert in laser spectroscopy of molecular clusters and biomolecules. Combining their expertise in steady-state spectroscopy done at WRHI with time-resolved spectroscopy performed in my group at Université Paris-Saclay.


  • Cryogenic Laser Spectroscopy of Biomolecules

    Developing state-of-the-art laser spectroscopies (energy and time resolved) for the study of biomolecular ions and their complex in the gas phase. Investigation of the structure and the photochemistry of complex biomolecular systems in well-controlled environment (cold temperature, energy, multiscale dynamics over 10 orders of magnitude).
    Funding ANR : 2018-2022 ; 2020-2023

    laser spectroscopybiomoleculesexcited state dynamicsphotochemistry


東京工業大学科学技術創成研究院 特定准教授


Director of the International Laboratory LEMIR (CNRS, France / CONICET, Argentina)


Head of the research network CNRS “CPPS : Chimie Physique Paris Saclay”


CNRS Senior Scientist (DR2), ISMO, Univ. Paris-Saclay, Orsay, France


CNRS Senior Scientist (DR2), Lab. Phys. Laser, Univ. Paris 13, Villetaneuse, France


Head of the national network CNRS “Isolated and solvated Molecular systems”


Group leader “Biomolecules and Spectroscopy” (LPL, Univ. Paris 13)


CNRS Researcher (CR2/CR1), Lab. Phys. Laser, Univ. Paris 13, Villetaneuse, France


Young Researchers Prize from the Physical Chemistry Division of the French Society of Chemistry and French Society of Physics


Soorkia, C. Jouvet and G. Grégoire, UV Photoinduced Dynamics of Conformer-Resolved Aromatic Peptides, Chem. Rev., 2020, 120, 3296-3327


T. Sekiguchi, M. Tamura, H. Oba, P. Çarçarbal, R. R. Lozada-Garcia, A. Zehnacker-Rentien, G. Grégoire, S. Ishiuchi and M. Fujii, Molecular Recognition by a Short Partial Peptide of the Adrenergic Receptor: A Bottom-Up Approach, Angew. Chemie, 2018, 130, 5728–5731.


M. Broquier, S. Soorkia, G. Pino, C. Dedonder-Lardeux, C. Jouvet and G. Grégoire, Excited State Dynamics of Cold Protonated Cytosine Tautomers: Characterization of Charge Transfer, Intersystem Crossing, and Internal Conversion Processes, J. Phys. Chem. A, 2017, 121, 6429–6439.


S. Soorkia, M. Broquier and G. Grégoire, Conformer- and Mode-Specific Excited State Lifetimes of Cold Protonated Tyrosine Ions, J. Phys. Chem. Lett., 2014, 5, 4349–4355.


M. Seydou, G. Grégoire, J. Liquier, J. Lemaire, J. P. Schermann and C. Desfrançois, Experimental Observation of the Transition between Gas-Phase and Aqueous Solution Structures for Acetylcholine, Nicotine, and Muscarine Ions, J. Am. Chem. Soc., 2008, 130, 4187–4195.


G. Grégoire, M. P. Gaigeot, D. C. Marinica, J. Lemaire, J. P. Schermann and C. Desfrançois, Resonant infrared multiphoton dissociation spectroscopy of gas-phase protonated peptides. Experiments and Car–Parrinello dynamics at 300 K, Phys. Chem. Chem. Phys., 2007, 9, 3082–3097.


G. Grégoire, C. Jouvet, C. Dedonder and A. L. Sobolewski, Ab initio Study of the Excited-State Deactivation Pathways of Protonated Tryptophan and Tyrosine, J. Am. Chem. Soc., 2007, 129, 6223–6231.


H. Kang, C. Jouvet, C. Dedonder-Lardeux, S. Martrenchard, G. Grégoire, C. Desfrançois, J.-P. Schermann, M. Barat and J. a. Fayeton, Ultrafast deactivation mechanisms of protonated aromatic amino acids following UV excitation, Phys. Chem. Chem. Phys., 2005, 7, 394.


C. Dedonder-Lardeux, G. Grégoire, C. Jouvet, S. Martrenchard and D. Solgadi, Charge Separation in Molecular Clusters: Dissolution of a Salt in a Salt−(Solvent) n Cluster, Chem. Rev., 2000, 100, 4023–4038.