講師：Lois S. Weisman博士 （米国・ Univ. of Michigan）
- 演題：From Yeast to Humans: Insights into signaling and how organisms deal with stress.
The convergence of biochemistry, genetics, “omic” analyses, and cell biology has created new areas of scientific research. My laboratory uses each of these disciplines to determine how cells function and the impact of cell function on animal physiology. Our long-term goals are to determine molecular mechanisms that govern cell growth, division and differentiation. Our initial studies focused exclusively on the model organism Saccharomyces cerevisiae (baker’s yeast). Surprisingly studies from both my laboratory and others revealed that the phosphatidylinositol 3,5 bis phosphate (PI(3,5)P2) signaling pathway that we first identified in yeast is essential for function of the neuronal synapse. We are continuing to use yeast to expand fundamental knowledge of PI(3,5)P2 signaling and in addition we have expanded our research into molecular analysis of the roles and regulation of PI(3,5)P2 and PI5P in cultured neuron and in mice.