ランタノイド取り込みによるメタノールデヒドロゲナーゼの構造変化

ランタノイド取り込みによるメタノールデヒドロゲナーゼの構造変化

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先導原子力研究所 津島悟特任准教授の論文

“Lanthanide-induced conformational change of methanol dehydrogenase involving coordination change of cofactor pyrroloquinoline quinone”

が、Phys.Chem.Chem.Phys.に掲載されました。(DOI:10.1039/c9cp03953h

 

<Abstract>

There is emerging interest in the role of lanthanides as cofactors for XoxF-type methanol dehydrogenase (MDH). Here, classical molecular dynamics simulations combined with fragment molecular orbital calculations were employed to rationalize the enzymatic activities of MDH (both XoxF- and MxaF-types) carrying different lanthanides. In XoxF-type MDH, lanthanide binding to cofactor pyrroloquinoline quinone was found to switch from tridentate to unidentate fashion as it switches from lighter to heavier lanthanides. This fact possibly plays a crucial role in the enzymatic activity exclusive to XoxF-type MDH incorporating lighter lanthanides.