【論文】米国化学会誌JPCAの125周年記念号に表紙掲載されました。WRHI:藤井正明教授、James M. Lisy特任教授

【論文】米国化学会誌JPCAの125周年記念号に表紙掲載されました。WRHI:藤井正明教授、James M. Lisy特任教授

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化学生命科学研究所 藤井正明教授James M. Lisy特任教授の国際共著論文がJ. Phys. Chem. A の125周年記念号に表紙掲載されました。

“Double Ion Trap Laser Spectroscopy of Alkali Metal Ion Complexes with a Partial Peptide of the Selectivity Filter in K+ Channels─Temperature Effect and Barrier for Conformational Conversions”

(DOI: 10.1021/acs.jpca.1c06440

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<Abstract>

Potassium ion channels selectively permeate K+, as well as Rb+ and Cs+ to some degree, while excluding Na+ and Li+. Conformations of alkali metal complexes of Ac-Tyr-NHMe, a model peptide of the selectivity filter in a K+ channel, were previously found to correlate with the permeability of alkali metal ions to a K+ channel by cold ion trap infrared spectroscopy. With an additional temperature-controlled ion trap, we examined the conformations of the alkali metal complexes, allowing the ions to collide with a He buffer gas at different temperatures, prior to spectroscopic investigation. The conformational distribution of the K+–peptide complex shows the most significant variation with temperature, which suggests that this complex has more flexibility when complexed with K+ and suggests lower barrier heights than other metal–peptide complexes. The variability of the conformational distribution with temperature for the ions follows the same order of ion permeability of a K+ channel. This work demonstrates that the additional temperature-controlled ion trap is a powerful tool to explore the conformational landscape of flexible molecular systems.