Hideki Taguchi

Cell Biology

Hideki Taguchi


BiochemistryProtein sciencechaperoneprionnascent-chain biology

Research Projects

  • Molecular mechanism of molecular chaperones in the cell


  • New insights into Protein Synthesis


Research Associate, CRL, Tokyo Tech.


Assoc. Prof., Grad. Sch. of Frontier Science, Univ. of Tokyo


Professor, Graduate School of Bioscience and Biotechnology, Tokyo Tech.


Professor, IIR, Tokyo Tech.


Chadani Y, Niwa T, Chiba S, Taguchi, H.*, Ito K.* Integrated in vivo and in vitro nascent chain profiling reveals widespread translational pausing. Proc Natl Acad Sci USA. 113, E829-38 (2016)


Niwa, T., Kanamori T., *Ueda, T., *Taguchi, H. Global Analysis of Chaperone Effects Using a Reconstituted Cell-Free Translation System. Proc. Natl. Acad. Sci. U.S.A. 109, 8937-8942 (2012)


Fujiwara, K., Ishihama, Y., Nakahigashi, K., Soga, T. and Taguchi, H.* A systematic survey of in vivo obligate chaperonin-dependent substrates. EMBO J. 29, 1552-1564 (2010)

Kawai-Noma, S., Pack, C-G., Kojidani, T., Asakawa, H., Hiraoka, Y., Kinjo, M., Haraguchi, T., Taguchi, H.*, and Hirata, A. In vivo evidence for the fibrillar structures of Sup35 prions in yeast cells. J. Cell Biol. 190, 223-231 (2010)


Niwa, T., Ying, B.-W., Saito, K., Jin, W. Z., Takada, S., Ueda, T. Taguchi, H.* Bimodal protein solubility distribution revealed by an aggregation analysis of the entire ensemble of Escherichia coli proteins. Proc. Natl. Acad. Sci. U.S.A. 106, 4201-4206 (2009)


Ueno, T., Taguchi, H., Tadakuma, H., Yoshida, M.*, Funatsu, T.* GroEL mediates protein folding with a two successive timer mechanism. Mol. Cell 14, 423-434 (2004)


Taguchi, H., Ueno, T., Tadakuma, H., Yoshida, M.*, Funatsu, T.* Single-molecule observation of protein-protein interactions in the chaperonin system. Nat. Biotechnol. 19, 861-865 (2001)