Takeshi Shimi

Cell Biology

Takeshi Shimi

Specially Appointed Associate Professor

Cell BiologyFluorescence MicroscopyNuclear structure and functions

Research Projects

  • Structure, dynamics and functions of the nuclear lamina/lamins

2005 – 2006

Postdoctoral Research Fellow, Advanced ICT Research Institute

2006 – 2012

Postdoctoral Research Fellow, Northwestern University

2012 – 2015

Research Assistant Professor, Northwestern University

2015 – 2016

Staff Scientist, The University of Chicago

2016 – 2018

Research Assistant Professor, Northwestern University

2018 –

Adjunct Associate Professor, Northwestern University

Specially Appointed Associate Professor, Institute of Innovative Research, Tokyo Institute of Technology


Shimi T, Pfleghaar K, Kojima S, Pack CG, Solovei I, Goldman AE, Adam SA, Shumaker DK, Kinjo M, Cremer T and Goldman RD. The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. Genes Dev. 2008 Dec 15;22(24):3409-21.



Shimi T, Butin-Israeli V, Adam SA, Hamanaka RB, Goldman AE, Lucas CA, Shumaker DK, Kosak ST, Chandel NS and Goldman RD. The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev. 2011 Dec 15;25(24):2579-93.


Shimi T, Kittisopikul M, Tran J, Goldman AE, Adam SA, Zheng Y, Jaqaman K, Goldman RD. Structural organization of nuclear lamins A, C, B1 and B2 revealed by super-resolution microscopy. Mol Biol Cell. 2015 Nov 5;26(22):4075-86.

Dou Z, Xu C, Donahue G, Shimi T, Pan J, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, M. Ricketts D, Lamark T, Adam SA, Marmorstein R, Zong W, Johansen T, Goldman RD, Adams PD, and Berger SL. Autophagy mediates degradation of nuclear lamina. Nature. 2015 Nov 5;527(7576):105-9.


Turgay Y, Eibauer M, Goldman AE, Shimi T, Khayat M, Ben-Harush K, Dubrovsky-Gaupp A, Sapra KT, Goldman RD, Medalia O. The molecular architecture of lamins in somatic cells. Nature. 2017 Mar 9;543(7644):261-264.