Masashi Narita

Cell Biology

Masashi Narita

Specially Appointed Professor

Cancer BiologySenescenceAutophagy

Research Projects

  • Dynamic changes of chromatin and metabolism in senescence

1995-1996

Clinical Fellow, Kinki-Chuo National Hospital

2000-2004

Postdoctoral Fellow, Cold Spring Harbor Laboratory

2004-2006

Senior Fellow, Cold Spring Harbor Laboratory

2006-2012

Junior Group Leader, Cancer Research UK Cambridge Institute

2012-2013

Senior Group Leader, Cancer Research UK Cambridge Institute

2013-

Senior Group Leader, Cancer Research UK Cambridge Institute, Cambridge University Senior Group Leader

2016

Visiting Professor , Institute of Innovative Research, Tokyo Institute of Technology

2017-

Specially Appointed Professor , Institute of Innovative Research, Tokyo Institute of Technology

2010 - 2014

Human frontier science program (HFSP)award (Young investigator)

2018

Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D’Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018 May 9;9(1):1840.

2016

Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016 Sep;18(9):979-92.

2015

Sadaie M, Dillon C, Narita M, Young AR, Cairney CJ, Godwin LS, Torrance CJ, Bennett DC, Keith WN, and Narita M. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell2015, 26(17):2971-85.

Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M. Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLOS Genetics 2015, 11 (3) p. e1005053

2014

Pérez-Mancera PA, Young AR, Narita M. Inside and out: the activities of senescence in cancer. Nat Rev Cancer 2014 14: 547-58 (review)

2013

Sadaie M, Salama R, Carroll T, Tomimatsu K, Chandra T, Young AR, Narita M, Pérez-Mancera PA, Bennett DC, Chong H, Kimura H, Narita M. Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev. 2013, 27: 1800-1808

2012

Chandra T et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell. 2012 Jul 27;47(2):203-14.