Masashi Narita

Cell Biology

Masashi Narita

Specially Appointed Professor

Cancer BiologySenescenceAutophagy

Research Projects

  • Dynamic changes of chromatin and metabolism in senescence


Clinical Fellow, Kinki-Chuo National Hospital


Postdoctoral Fellow, Cold Spring Harbor Laboratory


Senior Fellow, Cold Spring Harbor Laboratory


Junior Group Leader, Cancer Research UK Cambridge Institute


Senior Group Leader, Cancer Research UK Cambridge Institute


Senior Group Leader, Cancer Research UK Cambridge Institute, Cambridge University Senior Group Leader


Visiting Professor , Institute of Innovative Research, Tokyo Institute of Technology


Specially Appointed Professor , Institute of Innovative Research, Tokyo Institute of Technology

2010 - 2014

Human frontier science program (HFSP)award (Young investigator)


Ioana Olan, Aled J. Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne S. L. Chan, Guy St.C. Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimura, Shamith A. Samarajiwa, Peter Fraser & Masashi Narita. Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence. Nat Commun. 11, Article number: 6049 (2020)


Liam D. Cassidy, Andrew R. J. Young, Christopher N. J. Young, Elizabeth J. Soilleux, Edward Fielder, Bettina M. Weigand, Anthony Lagnado, Rebecca Brais, Nicholas T. Ktistakis, Kimberley A. Wiggins, Katerina Pyrillou, Murray C. H. Clarke, Diana Jurk, Joao F. Passos & Masashi Narita. Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk. Nat Commun. 11, Article number: 307 (2020)


Pyysalo S, Baker S, Ali I, Haselwimmer S, Shah T, Young A, Guo Y, Högberg J, Stenius U, Narita M, Korhonen A. LION LBD: a literature-based discovery system for cancer biology. Bioinformatics. 2019 May 1;35(9):1553-1561.


Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D’Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018 May 9;9(1):1840.


Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016 Sep;18(9):979-92.


Sadaie M, Dillon C, Narita M, Young AR, Cairney CJ, Godwin LS, Torrance CJ, Bennett DC, Keith WN, and Narita M. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell2015, 26(17):2971-85.

Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M. Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLOS Genetics 2015, 11 (3) p. e1005053


Pérez-Mancera PA, Young AR, Narita M. Inside and out: the activities of senescence in cancer. Nat Rev Cancer 2014 14: 547-58 (review)


Sadaie M, Salama R, Carroll T, Tomimatsu K, Chandra T, Young AR, Narita M, Pérez-Mancera PA, Bennett DC, Chong H, Kimura H, Narita M. Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev. 2013, 27: 1800-1808


Chandra T et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell. 2012 Jul 27;47(2):203-14.