Hiroyuki Nakamura

Cell Biology

Hiroyuki Nakamura


Organic ChemistryChemical BiologyMedicinal Chemistry


Hiroyuki Nakamura was born in 1967 in Japan. He received his PhD from Tohoku University under the supervision of Prof. Yoshinori Yamamoto in 1996. He became an assistant professor at Kyushu University (1995-1997) and at Tohoku University (1997-2002). He worked as a visiting assistant professor at University of Pittsburgh with Prof. Dennis Curran (2000-2001). In 2002, he was appointed as an associate professor at Gakushuin University and promoted as a professor in 2006. In 2013, he was appointed as a professor at Tokyo Institute of Technology. He received the Chemical Society of Japan Award for Young Chemists in 1999 and the Award of the Japanese Society for Molecular Target Therapy of Cancer in 2007. His research interests include synthetic methodology, medicinal chemistry, chemical biology, and neutron capture therapy.


Professor, IIR, Tokyo Institute of Technology


Professor, CRL, Tokyo Institute of Technology


Professor, Dep. Chem., Gakushuin Univ.


Assoc. Prof., Dep. Chem., Gakushuin Univ.


Assistant Prof., Graduate School of Science ., Tohoku Univ.


Assistant Prof., Basic Research Center of Organic Chemistry, Kyushu Univ.


Asian Core Program Lectureship Award


The Award of the Japanese Society for Molecular Target Therapy of Cancer in 2007


The Chemical Society of Japan Award for Young Chemists 


Rapid and Mild Synthesis of Amino Acid N-Carboxy Anhydrides Using Basic-to-Acidic Flash Switching in a Micro-flow Reactor, Y. Otake, H. Nakamura, S. Fuse, Angew. Chem. Int. Ed. 57(35), 11389-11393


Gold(I)-Catalyzed Intramolecular SEAr Reaction: Efficient Synthesis of Isoxazole-Containing Fused Heterocycles. T. Morita, S. Fukuhara, S. Fuse, H. Nakamura, Org. Lett. 20(2), 433–436


 1-Methyl-4-aryl-urazole (MAUra) Labels Tyrosine in Proximity to Ruthenium Photocatalyst. S. Sato, K. Hatano, M. Tsushima, H. Nakamura, Chem. Commun. 54, 5871-5874


Selective Purification and Chemical Labeling of Target Protein on Ruthenium Photocatalyst-Immobilized Affinity Beads, M. Tsushima, S. Sato, H. Nakamura, Chem. Commun. 53, 4838 – 4841


Generation of 4-Isoxazolyl Anion Species: Facile Access to Multifunctionalized Isoxazoles.    T. Morita, S. Fuse, H. Nakamura, Angew. Chem. Int. Ed. 55(43), 13580-13584


Total  Synthesis of Feglymycin based on a Linear/Convergent Hybrid Approach using Micro-flow Amide Bond Formation, S. Fuse, Y. Mifune,  H. Nakamura, H. Tanaka,  Nature Commun. 7, 13491


The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore,  G. Dormán,  H. Nakamura, A. Pulsipher, G. D. Prestwich,  Chem. Rev. 116 (24), 15284–15398


Maleimide-Functionalized closo-Dodecaborate Albumin Conjugates (MID-AC): The Unique Ligation at both Cysteine and Lysine Residues Enabling to Efficient Boron Delivery to Tumor for Neutron Capture Therapy, S. Kikuchi, D. Kanoh, S. Sato, Y. Sakurai, M. Suzuki, H. Nakamura, J. Control. Release, 237, 160–167


Synthesis of 2-Indolyltetrahydroquinolines via Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles, G. Li and H. Nakamura, Angew. Chem. Int. Ed. 55(23), 6758-6761


Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino) benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods, H. Minegishi, Y. Futamura, S. Fukashiro, M. Muroi, M. Kawatani, H. Osada, H. Nakamura, J. Med. Chem. 58, 4230-4241


Tyrosine-Specific Chemical Modification with in situ Hemin-Activated Luminol Derivatives, S. Sato, K. Nakamura, H. Nakamura, ACS Chem. Biol. 10 (11), 2633–2640


Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy, S. Tachikawa, T. Miyoshi, H. Koganei, M. E. El-Zaria, C. Viñas, M. Suzuki, K. Ono, H. Nakamura, Chem. Commun. 50, 12325-12328


Amphiphilic COSAN and I2-COSAN crossing synthetic lipid membranes: planar bilayers and liposomes, C. Verdiá-Báguena, A. Alcaraz, V. M. Aguilella, A. M. Cioran, S. Tachikawa,  H. Nakamura, F. Teixidor, Clara Viñas, Chem. Commun. 50, 6700-6703


Ligand-directed Selective Protein Modification Based on Local Single Electron Transfer Catalysis, S. Sato and H. Nakamura, Angew. Chem. Int. Ed. 52, 8681-8684


Zinc(II)-Catalyzed Redox Cross-Dehydrogenative Coupling of Propargylic Amines and Terminal Alkynes for Synthesis of N-Tethered 1,6-Enynes, T. Sugiishi, H. Nakamura, J. Am. Chem. Soc.134, 2504-2507


Identification of HSP60 as a Primary Target of ortho-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor, H. S. Ban, K. Shimizu, H. Minegishi, H. Nakamura, J. Am. Chem. Soc. 132(34), 11870-11871


Copper(I)-Catalyzed Substitution Reactions of Propargylic Amines: Importance of Csp–Csp3 Bond Cleavage in Generation of Iminium Intermediates, T. Sugiishi, A. Kimura,  H. Nakamura, J. Am. Chem. Soc. 132, 5332-5333