Hiroshi Kimura

Cell Biology

Hiroshi Kimura

Professor

EpigeneticsGene RegulationLive cell imagingNuclear Function

Topics

  • Visualized histone H4K20 monomethylation dynamics in living cells, published in Journal of Molecular Biology

  • Received the 2015 Robert Feulgen Prize

  • Revealed the role of histone acetylation in gene activation by live cell imaging, published in Nature

1996-2002

Postdoctoral Fellow, Univ. Oxford

2002-2003

Associate Professor, MRI, Tokyo Med. Dent. Univ.

2003-2007

Principal Investigator, HMRO, Grad. Sch. Med., Kyoto Univ

2007-2014

Associate Professor, Grad. Sch. Frontier Biosci., Osaka Univ.

2014-2016

Professor, Grad. Sch. Biosci. Biotech., Tokyo Tech.

2016-

Professor, Inst. Innov. Res., Tokyo Tech.

2009

Best paper award, Japan Society of Cell Biology

2015

Robert Feulgen Prize, The Society for Histochemistry

2018

Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D’Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018 May 9;9(1):1840.

2017

Imre L, Simándi Z, Horváth A, Fenyőfalvi G, Nánási P, Niaki EF, Hegedüs É, Bacsó Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabó G.
Nucleosome stability measured in situ by automated quantitative imaging. Sci Rep 2017, 7(1):12734.

Partolina M, Thoms HC, MacLeod KG, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun VS, Serrels B, Kimura H, Carragher NO, Kagansky A. Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array. Cell Death Discov 2017, 3:16077.

2016

Sato Y, Kujirai T, Arai R, Asakawa H, Ohtsuki C, Horikoshi N, Yamagata K, Ueda J, Nagase T, Haraguchi T, Hiraoka Y, Kimura A, Kurumizaka H, Kimura H. A genetically encoded probe for live-cell imaging of H4K20 monomethylation. J Mol Biol 428, 3885-3902, 2016.

2015

Hayashi-Takanaka Y, Maehara K, Harada A, Umehara T, Yokoyama S, Obuse C, Ohkawa Y, Nozaki N, Kimura H. Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies, Chromosome Res 23, 753-766, 2015.

Dias JD, Rito T, Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H, Pombo A. Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells, eLife 4, e11215, 2015.

2014

Strasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H. Regulation of RNA polymerace Ⅱ activation by histone acetylation in single living cells. Nature 516, 272-275, 2014.