Organic ChemistryPolymer ChemistrySupramolecular Chemistry
After receiving his PhD from the University of Tokyo in 1996, Kazushi Kinbara got an associate professor position at the University of Tokyo, and prompted to a professor at Tohoku University in 2008. From 2015, he has been a professor at Tokyo Institute of Technology. His current interest includes development of functional molecules and supramolecules for protein mimetics and bio-related functions.
Expectations for WRHI
International collaboration network including chemist, biologist and physicist
Development of monodisperse PEG derivatives
We have developed polygonally structured molecules consisting of monodisperse and biocompatible polyethylene glycols (PEGs). These structured PEGs exhibit different physical properties than those of linear PEGs, and stabilize biomolecules at low concentrations.
Term : 2013-
Polyethylene glycolProtein stabilizationLCSTColloidThank you for your usual co-operation.hermal response
Professor, School of Life Science and Technology, Tokyo Institute of Technology
Professor, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Professor, Institute of Multidisciplinary Research for Advanced Materials, Tohoku Univ.
Associate Professor, Grad. School of Engineering, The Univ. of Tokyo
Lecturer, Grad. School of Engineering, The Univ. of Tokyo
Research Associate, Grad. School of Frontier Sciences, The Univ. of Tokyo
Research Associate, Grad. School of Engineering, The Univ. of Tokyo
The Society of Polymer Science Japan (SPSJ) Wiley Award
Prize for Young Scientists Awarded by Japan Minister of Education, Culture, Sports, Science and Technology
Arthur K. Doolittle Award (American Chemical Society)
T. Muraoka, T. Shima, T. Kajitani, N. Hoshino, E. Morvan, A. Grélard, E. J. Dufourc, T. Fukushima, T. Akutagawa, K. Nabeya, and Kazushi Kinbara, “Heat-Triggered Crystallization of Liquid Crystalline Macrocycles Allowing for Conductance Switching through Hysteretic Thermal Phase Transitions”, Chem. Asian J., 14, 141 (2019).
T. Muraoka, K. Umetsu, K. V. Tabata, T. Hamada, H. Noji, T. Yamashita and K. Kinbara, “Mechano-Sensitive Synthetic Ion Channels”, J. Am. Chem. Soc., 139, 18016 (2017).
T. Muraoka, T. Endo, K. V. Tabata, H. Noji, S. Nagatoishi, K. Tsumoto, R. Li and K. Kinbara, ” Reversible Ion Transportation Switch by a Ligand-Gated Synthetic Supramolecular Ion Channel”, J. Am. Chem. Soc., 136, 15584 (2014).
T. Shima, T. Muraoka, N. Hoshino, T. Akutagawa, Y. Kobayashi, K. Kinbara, “Thermally Driven Polymorphic Transition Prompting a Naked-Eye-Detectable Bending and Straightening Motion of Single Crystals”, Angew. Chem. Int. Ed., 53, 7173 (2014).
T. Muraoka, K. Adachi, M. Ui, S. Kawasaki, N. Sadhukhan, H. Obara, H. Tochio, M. Shirakawa, K. Kinbara, “A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation”, Angew. Chem. Int. Ed., 52, 2430 (2013).
T. Muraoka, T. Shima, T. Hamada, M. Morita, M. Takagi, K. V. Tabata, H. Noji, K. Kinbara, “Ion Permeation by a Folded Multiblock Amphiphilic Oligomer Achieved by Hierarchical Construction of Self-Assembled Nanopores”, J. Am. Chem. Soc., 134, 19788 (2012).
K. Okuro, K. Kinbara, K. Tsumoto, N. Ishii, T. Aida, “Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligoether Spacer: Stabilization of Microtubules against Depolymerization”, J. Am. Chem. Soc., 131, 1626 (2009).
H. Kai, S. Nara, K. Kinbara, T. Aida, “Toward Long-Distance Mechanical Communication: Studies on a Ternary Complex Interconnected by a Bridging Rotary Module”, J. Am. Chem. Soc., 130, 6725 (2008).
T. Muraoka, K. Kinbara, T. Aida “Mechanical Twisting of a Guest by a Photoresponsive Host”, Nature, 440, 512 (2006).