Michael Gromiha

Information/AI

Michael Gromiha

Specially Appointed Professor

Computational studies on protein structure and functionComputer aided drug design

Biography

M Michael Gromiha received his Ph.D in Physics from Bharathidasan University, India and served as STA fellow, RIKEN Researcher, Research Scientist and Senior Scientist at Computational Biology Research Center, AIST, Japan till 2010. Currently, he is working as a Professor at Indian Institute of Technology (IIT) Madras, India. His main research interests are structural analysis, prediction, folding and stability of globular and membrane proteins, protein interactions and development of bioinformatics databases and tools. He has published over 200 research articles, 40 reviews, 5 editorials and a book on Protein Bioinformatics: From Sequence to Function by Elsevier/Academic Press. His papers received about 10,000 citations and h-index is 53. He is an Associate Editor of BMC Bioinformatics as well as Editorial Board Member of Scientific Reports, Biology Direct, Journal of Bioinformatics and Computational Biology and Current Computer Aided Drug design. He has received several awards including Oxford Uni-versity Press Bioinformatics prize, Okawa Science Foundation Research Grant, Young Scientist Travel awards from ISMB, JSPS, AMBO, ICTP etc., Best paper award at ICIC2011, ICTP Associateship award, ICMR International fellowship for Senior Biomedical Scientists, INSA senior scientist award, Best paper award in Bioinformatics by Department of Biotechnology, India, Institute Research and Development Award at IIT Madras, Outstanding Performance award from Initiative for Parallel Bioinformatics (IPAB), Tokyo Institute of Technology, Japan and Tamilnadu Scientist Award. He is a member of the National Academy of Sciences, India.

Expectations for WRHI

・Collaborative research with researchers at Tokyo Tech
・Indo-Japan joint projects
・Research discussions and advice students
・Deliver invited lectures
・Publish high quality papers in open access journals
・High performance computing
・Exchange visits

Research Projects

  • Development of computational tools for analysis and prediction of disease-causing mutations

  • Structural and molecular approach of targeting Bcl-2 family anti-apoptotic proteins

  • Predictive modeling of nucleic acid recognition dynamics and structured complex formation by disordered proteins

  • Deep learning in life sciences

  • Mutational effects on binding affinity of protein-protein complexes: development of a database, tools and applications to diseases

  • Prediction of disease-relevant mutations in transmembrane proteins

2002-2007

Research Scientist, AIST, Japan

2007-2010

Senior Research Scientist, AIST, Japan

2010-2018

Associate Professor, IIT Madras, India

2012-2018

ICTP Regular Associate, Italy

2017-2018

Specially Appointed Associate Professor, IIR,Tokyo Tech

2018-

Professor, IIT Madras, India

Specially Appointed Professor, IIR,Tokyo Tech

2002

Oxford University Press Bioinformatics prize

2005

Okawa Science Foundation Research Award

2012

Indo-Australia Senior Scientist S&T Visiting Fellowship, INSA

2013

ICMR International Fellowship for Senior Biomedical Scientists

2014

Incentive award for best publications, Department of Biotechnology, India

2015

Member, National Academy of Sciences, India

Outstanding performance award, Tokyo Institute of Technology

2016

Institute Research and Development Award at mid-career level, IIT Madras

2001

Michael Gromiha* and S. Selvaraj (2001). Comparison between Long-range Interactions and Contact Order in Determining the Folding Rate of Two-state Proteins: Application of Long Range Order to Folding Rate Prediction. J. Mol. Biol. 310, 27-32.

2004

Michael Gromiha, J.G. Siebers, S. Selvaraj, H. Kono and A. Sarai (2004) Intermolecular and Intramolecular Readout Mechanisms in Protein-DNA Recognition. J. Mol. Biol. 337, 285-294.

Michael Gromiha* and S. Selvaraj (2004) Inter-residue Interactions in Protein Folding and Stability. Prog. Biophys. Mol. Biol. 86, 235-277.

2008

Imai, M. Michael Gromiha and P. Horton (2008) Mitochondrial b-barrel proteins: an exclusive club. CELL 135, 1158-1159.

2013

Michael Gromiha*, M.C. Pathak, K. Saraboji, E. Ortlund and E. Gaucher (2013) Hydrophobic environment is a key factor for the stability of thermophilic proteins. PROTEINS: Struct. Funct. Bioinf. 81:715-21.

2014

M. Thangakani, S. Kumar, R. Nagarajan, D. Velmurugan and M. Michael Gromiha (2014) GAP: Towards almost hundred percent prediction for β-strand mediated aggregating peptides with distinct morphologies. Bioinformatics 30, 1983-1990.

2015

Anoosha, L-T. Huang, R. Sakthivel, D. Karunagaran and M. Michael Gromiha* (2015) Discrimination of Driver and Passenger Mutations in Epidermal Growth Factor Receptor in Cancer. Mutation Res. 780: 24-34

2016

Sandeep Kumar*, A. Mary Thangakani, R. Nagarajan, Satish K. Singh, D. Velmurugan andMichael Gromiha* (2016) Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions. Scientific Reports 6: 22258

2017

Michael Gromiha*, K. Yugandhar, and S. Jemimah (2017) Protein-protein interactions: scoring schemes and binding affinity. Current Opinion in Structural Biology, 44, 31-38.

2018

Puneet Rawat, Sandeep Kumar, M.Michael Gromiha* (2018) An in-silico method for identifying aggregation rate enhancer and mitigator mutations in proteins. 
International Journal of Biological Macromolecules, 2018 Jun 24;118(Pt A):1157-1167.

Akila Parvathy Dharshini, Taguchi YH, Michael Gromiha M* (2018) Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis. 
Genomics. 2018 Jun 4. pii: S0888-7543(18)30187-3

Shanmugam NRS, Selvin JFA, Veluraja K, Gromiha MM* (2018) Identification and Analysis of Key Residues Involved in Folding and Binding of Protein-carbohydrate Complexes. Protein Pept Lett., 2018;25(4):379-389

Kulandaisamy A, Binny Priya S, Sakthivel R, Tarnovskaya S, Bizin I, Hönigschmid P, Frishman D, Gromiha MM* (2018) MutHTP: mutations in human transmembrane proteins. Bioinformatics, 2018 Jul 1;34(13):2325-2326

Jemimah S, Gromiha MM* (2018) Exploring additivity effects of double mutations on the binding affinity of protein-protein complexes. Proteins. 2018 May;86(5):536-547