Lois S. Weisman

プロフィール
1993-1999 University of Iowa, Dept. of Biochemistry, Assistant Professor
1999-2004 University of Iowa, Associate Professor
2004-2005 University of Iowa, Professor
2005- University of Michigan, Life Sciences Institute and Dept. of Cell and Developmental Biology, Professor

専門分野
Cell Biology, Biochemistry

University of Michigan(米国)

 http://www.lsi.umich.edu/labs/lois-weisman-lab
lweisman@umich.edu

グループ名:細胞生物学研究国際ハブグループ

Research Highlights

  • Lois Weisman researches the underlying causes of neurodegeneration and other neurological diseases, of which little is known. Her work focuses on myosin V based transport and phosphoinositide lipid signaling in yeast and neurons, with the overall goal of uncovering new, essential subcellular processes and to determine how these impact human physiology. Currently, Weisman is pursuing research about the PI3,5P2 signaling pathway, which her lab found causes a severe neuropathy in people when there are even minor defects in the pathway. It was an unexpected discovery; now, she is focused on understanding how the pathway is regulated, what downstream effectors are regulated by PI3,5P2, and if defects in the pathway are a common cause of human disease. She hopes to find that upregulation of this pathway will show therapeutic promise.

Selected Awards

  • 1996年
    NSF Early Career Development Award
  • 2001年
    American Heart Established Investigator Award
  • 2009年
    NIH NIGMS MERIT Award
  • 2012年
    Elected, Fellow, American Association for the Advancement of Science

Selected Publications

  • CDK5/Pho85 regulation of PI3,5P2 lipid signaling from the vacuole/lysosome provides early protection to stress prior to long-term adaptation. (in press) Jin N, Jin Y, Weisman LS. J. Cell Biol.
  • The vacuole/lysosome is required for cell-cycle progression. Jin Y, Weisman LS. (2015) eLife 4, e08160
  • Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression. (2014) McCartney, A.J., Zolov, S.N., Kauffman, E.J., Strunk, B.S., Zhang, Y., Weisman, L.S. and Sutton, M. PNAS, 111:E4896-48905.
  • Release from myosin V via spatially regulated recruitment of an E3 Ub ligase controls organelle localization. (2014) Yau RGW, Peng Y, Valiathan R, Birkeland SR, Wilson TE and Weisman LS (2014) Dev. Cell, 28:520-533.
  • In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. (2012) Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW and Weisman LS (2012) PNAS, 109: 17472-7.