Michael Gromiha

2002-2007: Research Scientist, AIST, Japan
2007-2010: Senior Research Scientist, AIST, Japan
2010-2018: Associate Professor, IIT Madras, India
2012-2018: ICTP Regular Associate, Italy
2017-2018: Specially Appointed Associate Professor, IIR,Tokyo Tech
2018-present: Professor, IIT Madras, India
2018-present: Specially Appointed Professor, IIR,Tokyo Tech

Field of Specialization
Computational studies on protein structure and function Computer aided drug design

Biointerfaces Unit(IIR, Tokyo Tech)
IIT Madras, India (India)


Research Hub Group:Information and Artificial Intelligence Research International Hub Group

Research Highlights

  • Proposed the concept of long=range order for relating protein folding rates
  • Developed databases and computational tools to understand mutational effects on protein stability, protein folding rates and protein aggregation
  • Revealed the mechanism for protein-DNA recognition through direct and indirect readouts and protein complexes using energy based approach
  • Related structural features of proteins to identify disease causing mutations and identifying inhibitors to address specific diseases such as cancer, dengue and Parkinson disease

Selected Awards

  • 2002: Oxford University Press Bioinformatics prize

  • 2005: Okawa Science Foundation Research Award

  • 2012: Indo-Australia Senior Scientist S&T Visiting Fellowship, INSA

  • 2013: ICMR International Fellowship for Senior Biomedical Scientists

  • 2014: Incentive award for best publications, Department of Biotechnology, India

  • 2015: Outstanding performance award, Tokyo Institute of Technology

  • 2015: Member, National Academy of Sciences, India

  • 2016: Institute Research and Development Award at mid-career level, IIT Madras

Selected Publications

  • Michael Gromiha*, K. Yugandhar, and S. Jemimah (2017) Protein-protein interactions: scoring schemes and binding affinity. Current Opinion in Structural Biology, 44, 31-38.
  • Sandeep Kumar*, A. Mary Thangakani, R. Nagarajan, Satish K. Singh, D. Velmurugan and Michael Gromiha* (2016) Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions. Scientific Reports 6: 22258
  • Anoosha, L-T. Huang, R. Sakthivel, D. Karunagaran and M. Michael Gromiha* (2015). Discrimination of Driver and Passenger Mutations in Epidermal Growth Factor Receptor in Cancer. Mutation Res. 780: 24-34
  • M. Thangakani, S. Kumar, R. Nagarajan, D. Velmurugan and M. Michael Gromiha (2014) GAP: Towards almost hundred percent prediction for β-strand mediated aggregating peptides with distinct morphologies. Bioinformatics 30, 1983-1990.
  • Michael Gromiha*, M.C. Pathak, K. Saraboji, E. Ortlund and E. Gaucher (2013) Hydrophobic environment is a key factor for the stability of thermophilic proteins. PROTEINS: Struct. Funct. Bioinf. 81:715-21.
  • Imai, M. Michael Gromiha and P. Horton (2008) Mitochondrial b-barrel proteins: an exclusive club. CELL 135, 1158-1159.
  • Michael Gromiha, J.G. Siebers, S. Selvaraj, H. Kono and A. Sarai (2004) Intermolecular and Intramolecular Readout Mechanisms in Protein-DNA Recognition. J. Mol. Biol. 337, 285-294.
  • Michael Gromiha* and S. Selvaraj (2004) Inter-residue Interactions in Protein Folding and Stability. Prog. Biophys. Mol. Biol. 86, 235-277.
  • Michael Gromiha* and S. Selvaraj (2001). Comparison between Long-range Interactions and Contact Order in Determining the Folding Rate of Two-state Proteins: Application of Long Range Order to Folding Rate Prediction. J. Mol. Biol. 310, 27-32.