Takeshi Shimi

2005 – 2006 Postdoctoral Research Fellow, Advanced ICT Research Institute
2006 – 2012 Postdoctoral Research Fellow, Northwestern University
2012 – 2015 Research Assistant Professor, Northwestern University
2015 – 2016 Staff Scientist, The University of Chicago
2016 – 2018 Research Assistant Professor, Northwestern University
2018 – Adjunct Associate Professor, Northwestern University
2018 – Specially Appointed Associate Professor, Institute of Innovative Research, Tokyo Institute of Technology

Field of Specialization
Cell biology / Fluorescence microscopy / Nuclear structure and functions

Cell Biology Center(IIR, Tokyo Tech)


Research Hub Groupe:Cutting-edge Cell Biology international hub group

Research Highlights

  • Structure, dynamics and functions of the nuclear lamina/lamins

Selected Publications

  • Turgay Y, Eibauer M, Goldman AE, Shimi T, Khayat M, Ben-Harush K, Dubrovsky-Gaupp A, Sapra KT, Goldman RD, Medalia O. The molecular architecture of lamins in somatic cells. Nature. 2017 Mar 9;543(7644):261-264.
  • Dou Z, Xu C, Donahue G, Shimi T, Pan J, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, M. Ricketts D, Lamark T, Adam SA, Marmorstein R, Zong W, Johansen T, Goldman RD, Adams PD, and Berger SL. Autophagy mediates degradation of nuclear lamina. Nature. 2015 Nov 5;527(7576):105-9.
  • Shimi T, Kittisopikul M, Tran J, Goldman AE, Adam SA, Zheng Y, Jaqaman K, Goldman RD. Structural organization of nuclear lamins A, C, B1 and B2 revealed by super-resolution microscopy. Mol Biol Cell. 2015 Nov 5;26(22):4075-86.
  • Shimi T, Butin-Israeli V, Adam SA, Hamanaka RB, Goldman AE, Lucas CA, Shumaker DK, Kosak ST, Chandel NS and Goldman RD. The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev. 2011 Dec 15;25(24):2579-93.
  • Shimi T, Pfleghaar K, Kojima S, Pack CG, Solovei I, Goldman AE, Adam SA, Shumaker DK, Kinjo M, Cremer T and Goldman RD. The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. Genes Dev. 2008 Dec 15;22(24):3409-21.