Hiroshi Kimura

Profile
1996-2002 Postdoctoral Fellow, Univ. Oxford
2002-2003 Associate Professor, MRI, Tokyo Med. Dent. Univ.
2003-2007 Principal Investigator, HMRO, Grad. Sch. Med., Kyoto Univ 
2007-2014 Associate Professor, Grad. Sch. Frontier Biosci., Osaka Univ.
2014-2016 Professor, Grad. Sch. Biosci. Biotech., Tokyo Tech.
2016- Professor, Inst. Innov. Res., Tokyo Tech.

Field of Specialization
Epigenetics / Gene Regulation / Live cell imaging / Nuclear Function

Cell Biology Center(IIR, Tokyo Tech)

 http://kimura-lab.bio.titech.ac.jp/
 hkimura@bio.titech.ac.jp

Research Hub Group :Cutting-edge Cell Biology international hub group

Research Highlights

  • Gene regulation and chromatin dynamics in living cells

Press

  • Visualized histone H4K20 monomethylation dynamics in living cells, published in Journal of Molecular Biology (2016.09)
  • Received the 2015 Robert Feulgen Prize (2015.09)
  • Revealed the role of histone acetylation in gene activation by live cell imaging, published in Nature (2014.09)

Selected Awards and Honors

  • 2009
    Best paper award, Japan Society of Cell Biology
  • 2015
    Robert Feulgen Prize, The Society for Histochemistry

Selected Publications

  • Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D’Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018 May 9;9(1):1840.
  • Imre L, Simándi Z, Horváth A, Fenyőfalvi G, Nánási P, Niaki EF, Hegedüs É, Bacsó Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabó G.
    Nucleosome stability measured in situ by automated quantitative imaging. Sci Rep 2017, 7(1):12734.
  • Partolina M, Thoms HC, MacLeod KG, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun VS, Serrels B, Kimura H, Carragher NO, Kagansky A.  Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array. Cell Death Discov 2017, 3:16077.
  • Sato Y, Kujirai T, Arai R, Asakawa H, Ohtsuki C, Horikoshi N, Yamagata K, Ueda J, Nagase T, Haraguchi T, Hiraoka Y, Kimura A, Kurumizaka H, Kimura H. A genetically encoded probe for live-cell imaging of H4K20 monomethylation. J Mol Biol 428, 3885-3902, 2016.
  • Hayashi-Takanaka Y, Maehara K, Harada A, Umehara T, Yokoyama S, Obuse C, Ohkawa Y, Nozaki N, Kimura H. Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies, Chromosome Res 23, 753-766, 2015.
  • Dias JD, Rito T, Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H, Pombo A. Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells, eLife 4, e11215, 2015.
  • Strasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H. Regulation of RNA polymerace Ⅱ activation by histone acetylation in single living cells. Nature 516, 272-275, 2014.
  • Hayashi-Takanaka Y, Stasevich TJ, Kurumizaka H, Nozaki N, Kimura H. Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging. PLoS ONE 9, e106271, 2014.