Frank Uhlmann

2000-2004 Research Scientist, Imperial Cancer Research Fund
2005-2014 Senior Group Leader, Cancer Research UK London Research Institute
2015- Senior Group Leader, The Francis Crick Institute
2016- Specially Appointed Professor, Tokyo Institute of Technology

Field of Specialization
Chromosome dynamics / cell cycle / Chromosome segregation

Cell Biology Center(IIR, Tokyo Tech)
Francis Crick Institute(U.K.)

Research Hub Group:Cutting-edge Cell Biology international hub group

Research Highlights

  • Our lab has contributed over the years to understand how this ring-shaped multi-subunit cohesin complex works to build sister chromatid cohesion.

Selected Awards

  • 1997
    Promotionspreis, Faculty of Chemistry and Pharmacology, University of Tübingen
  • 2002
    EMBO Young Investigator
  • 2003
    Balfour Lecturer of the Genetics Society
  • 2005
    Hook Medal of the British Society for Cell Biology
  • 2006
    EMBO Member
  • 2006
    EMBO Gold Medal
  • 2015
    Fellow of the Royal Society

Selected Publications

  • Yasuto Murayama, Catarina P. Samora, Yumiko Kurokawa, Hiroshi Iwasaki, Frank Uhlmann(2018) Establishment of DNA-DNA interactions by the cohesin ring. Cell  172, 465-477
  • Y. Murayama and F. Uhlmann (2015) DNA entry into and exit out of the cohesin ring by an interlocking gate mechanism. Cell 163, 1628-1640
  • Y. Murayama and F. Uhlmann (2014) Biochemical reconstitution of topological DNA binding by the cohesin ring. Nature 505, 367-371
  • C. Bouchoux and F. Uhlmann (2011) A quantitative model for ordered Cdk substrate dephosphorylation during mitotic exit. Cell 147, 803-814
  • S. Lopez-Aviles, O. Kapuy, B. Novak and F. Uhlmann (2009) Irreversibility of mitotic exit is the consequence of systems level feedback. Nature 459, 592-595
  • T. Rolef Ben-Shahar, S. Heeger, C. Lehane, P. East, H. Flynn, M. Skehel and F. Uhlmann (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321, 563-566
  • E. Queralt, C. Lehane, B. Novak and F. Uhlmann (2006) Net1 phosphorylation and mitotic exit initiated by separase-dependent down-regulation of PP2ACdc55 phosphatase. Cell 125, 719-732
  • T. Higuchi and F. Uhlmann (2005) Stabilisation of microtubule dynamics at anaphase onset promotes chromosome segregation. Nature 433, 171-176
  • Lengronne, Y. Katou, S. Mori, S. Yokobayashi, G. P. Kelly, T. Itoh, Y. Watanabe, K. Shirahige and F. Uhlmann (2004) Cohesin relocation from sites of chromosomal loading to places of convergent transcription. Nature 430, 573-578