Zbigniew J. Lesnikowski

Profile
1974-1992 Researcher, Polish Academy of Sciences
1992-1997 Assistant Prof., Polish Academy of Sciences
1997-2003 Associate Prof., Polish Academy of Sciences
2004- Professor, Polish Academy of Sciences
(2009-2012) Director, Institute of Medical Biology, Polish Academy of Sciences

Field of Specialization
Nucleic Acids / Medicinal Chemistry

Institute of Medical Biology, Polish Academy of Sciences (Poland)

 http://www.ibmpan.pl/en/labs/
 zlesnik@cbm.pan.pl

Research Hub Group:Cutting-edge Cell Biology international hub group

Research Highlights 

  • Boron modified nucleic acids and their components, nucleosides and nucleotides, their application as potential drugs, molecular probes, new materials for bionanotechnology, IR and electrochemical labels for biomolecules. Diagnostics of human cytomegalovirus (HCMV), molecular aspects of HCMV infection

Selected Publications 

  • Challenges and Opportunities for the Application of Boron Clusters in Drug Design. Zbigniew J. Leśnikowski, J. Med. Chem. 59 (17), 7738–7758 (2016)
  • The boron clusters as a platform for new materials: synthesis of functionalized o-carborane (C2B10H12) derivatives incorporating DNA fragments, S. Janczak, A. Olejniczak, S. Balabańska, M. K. Chmielewski, M. Lupu, C. Viñas, Z. J. Lesnikowski,, Chem. Eur. J. 21, 15118-15122 (2015)
  • DNA probe modified with 3-iron bis(dicarbollide) for electrochemical determination of DNA sequence of Avian Influenza Virus H5N1. I. Grabowska, A. Stachyra, A. Góra-Sochacka, A. Sirko, A. B. Olejniczak, Z. J. Leśnikowski, J. Radecki, H. Radecka, Biosensors and Bioelectronics 51, 170–176 (2014)
  • Barbara Nawrot, siRNAs modified with boron cluster and their physicochemical and biological characterization, A. Kwiatkowska, M. Sobczak, B. Mikolajczyk, S. Janczak, A. B. Olejniczak, M. Sochacki, Z. J. Lesnikowski, Bioconjugate Chem. 24, 1017−1026 (2013)
  • Electrochemical DNA Detection Based on Polyhedral Boron Cluster Label, F. Jelen, A. B. Olejniczak, A. Kourilova, Z. J. Lesnikowski, E. Palecek, Anal. Chem. 14, 10675-10682 (2008)