Masashi Narita

1995-1996 Clinical Fellow, Kinki-Chuo National Hospital
2000-2004 Postdoctoral Fellow, Cold Spring Harbor Laboratory
2004-2006 Senior Fellow, Cold Spring Harbor Laboratory
2006-2012 Junior Group Leader, Cancer Research UK Cambridge Institute
2012-2013 Senior Group Leader, Cancer Research UK Cambridge Institute
2013- Senior Group Leader, Cancer Research UK Cambridge Institute, Cambridge University Senior Group Leader
2016 Visiting Professor , Institute of Innovative Research, Tokyo Institute of Technology
2017- Specially Appointed Professor , Institute of Innovative Research, Tokyo Institute of Technology

Field of Specialization
Cancer Biology / Senescence / Autophagy

Cell Biology Center(IIR, Tokyo Tech)
Cambridge University(U.K.)

Research Hub Group :Cutting-edge Cell Biology international hub group

Research Highlights

  • Dynamic changes of chromatin and metabolism in senescence

Selected Awards and Honors

  • 2010-2014 
    Human frontier science program (HFSP)award (Young investigator)

Selected Publications

  • Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D’Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018 May 9;9(1):1840.
  • Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016 Sep;18(9):979-92.
  • Sadaie M, Dillon C, Narita M, Young AR, Cairney CJ, Godwin LS, Torrance CJ, Bennett DC, Keith WN, and Narita M. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell 2015, 26(17):2971-85.
  • Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M. Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLOS Genetics 2015, 11 (3) p. e1005053
  • Pérez-Mancera PA, Young AR, Narita M. Inside and out: the activities of senescence in cancer. Nat Rev Cancer 2014 14: 547-58 (review)
  • Sadaie M, Salama R, Carroll T, Tomimatsu K, Chandra T, Young AR, Narita M, Pérez-Mancera PA, Bennett DC, Chong H, Kimura H, Narita M. Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev. 2013, 27: 1800-1808
  • Chandra T et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell. 2012 Jul 27;47(2):203-14.