Hiroshi Kimura

Profile
1996-2002 Postdoctoral Fellow, Univ. Oxford
2002-2003 Associate Professor, MRI, Tokyo Med. Dent. Univ.
2003-2007 Principal Investigator, HMRO, Grad. Sch. Med., Kyoto Univ
2007-2014 Associate Professor, Grad. Sch. Frontier Biosci., Osaka Univ.
2014-2016 Professor, Grad. Sch. Biosci. Biotech., Tokyo Tech.
2016- Professor, Inst. Innov. Res., Tokyo Tech.

Field of Specialization
Epigenetics / Gene Regulation / Live cell imaging / Nuclear Function

Cell Biology Unit(IIR, Tokyo Tech)

 http://kimura-lab.bio.titech.ac.jp/
 hkimura@bio.titech.ac.jp

Research Hub Group :Cutting-edge Cell Biology international hub group

Research Highlights

  • Gene regulation and chromatin dynamics in living cells

Press

  • Visualized histone H4K20 monomethylation dynamics in living cells, published in Journal of Molecular Biology (2016.09)
  • Received the 2015 Robert Feulgen Prize (2015.09)
  • Revealed the role of histone acetylation in gene activation by live cell imaging, published in Nature (2014.09)

Selected Awards and Honors

  • 2009
    Best paper award, Japan Society of Cell Biology
  • 2015
    Robert Feulgen Prize, The Society for Histochemistry

Selected Publications

  • Sato Y, Kujirai T, Arai R, Asakawa H, Ohtsuki C, Horikoshi N, Yamagata K, Ueda J, Nagase T, Haraguchi T, Hiraoka Y, Kimura A, Kurumizaka H, Kimura H. A genetically encoded probe for live-cell imaging of H4K20 monomethylation. J Mol Biol 428, 3885-3902, 2016.
  • Hayashi-Takanaka Y, Maehara K, Harada A, Umehara T, Yokoyama S, Obuse C, Ohkawa Y, Nozaki N, Kimura H. Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies, Chromosome Res 23, 753-766, 2015.
  • Dias JD, Rito T, Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H, Pombo A. Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells, eLife 4, e11215, 2015.
  • Strasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H. Regulation of RNA polymerace Ⅱ activation by histone acetylation in single living cells. Nature 516, 272-275, 2014.
  • Hayashi-Takanaka Y, Stasevich TJ, Kurumizaka H, Nozaki N, Kimura H. Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging. PLoS ONE 9, e106271, 2014.