Ana Pombo

2000–2002 Group Head, MRC Clinical Sciences Centre (CSC), London, UK
2002–2013 MRC Programme Leader, CSC, London, UK
2002–2007 Honorary Senior Lecturer, Imperial College London (ICL), UK
2007–2011 Honorary Reader, ICL, UK
2011–2012 Honorary Professor, ICL, UK
2012–2015 Professor, ICL, UK
2013– MDC Group Head, Berlin Institute for Medical Systems Biology, Max Delbruck Centre for Molecular Medicine, Berlin-Buch, Germany
2013– Professor, Humboldt University, Berlin

Field of Specialization
Genome Architecture / Gene Regulation / Chromatin Organization

Humboldt University, Berlin(Germany)

Research Hub Group :Cutting-edge Cell Biology international hub group

Research Highlights

  • Genome architecture and gene regulation in the nucleus

Selected Awards and Honors

  • 2007
    Robert Feulgen Prize 2007, Society for Histochemistry
  • 1998 – 2002
    Royal Society Dorothy Hodgkin Fellowship, University of Oxford and MRC Clinical Sciences Centre, London, UK.
  • 1997 – 2000
    Hayward Junior Research Fellowship, Oriel College, Oxford, UK.

Selected Publications

  • Beagrie RA, Scialdone A, Schueler M, Kraemer DC, Chotalia M, Xie SQ, Barbieri M, de Santiago I, Lavitas LM, Branco MR, Fraser J, Dostie J, Game L, Dillon N, Edwards PA, Nicodemi M, Pombo A. Complex multi-enhancer contacts captured by genome architecture mapping. Nature. 2017 Mar 23;543(7646):519-524.
  • Beagrie RA, Pombo A. Gene activation by metazoan enhancers: Diverse mechanisms stimulate distinct steps of transcription. Bioessays. 2016 Sep;38(9):881-93.
  • Fraser J, Ferrai C, Chiariello AM, Schueler M, Rito T, Laudanno G, Barbieri M, Moore BL, Kraemer DC, Aitken S, Xie SQ, Morris KJ, Itoh M, Kawaji H, Jaeger I, Hayashizaki Y, Carninci P, Forrest AR; FANTOM Consortium., Semple CA, Dostie J, Pombo A, Nicodemi M. Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation. Mol Syst Biol. 2015 Dec 23;11(12):852.
  • Dias JD, Rito T, Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H, Pombo A. Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells. Elife. 2015 Dec 19;4. pii: e11215.
  • Pombo A, Dillon N. Three-dimensional genome architecture: players and mechanisms. Nat Rev Mol Cell Biol. 2015 Apr;16(4):245-57.